![]() ![]() ![]() Immunostaining against glial-fibric-acidic protein also depicts proliferative glial cells in larger extent in APP-PS1 than WT mice, which correspond to the higher mIns concentration. The APP-PS1 mice show ~50% higher MICEST contrast than WT control with concomitant increase in mIns concentration as measured through proton spectroscopy. The high resolution mapping of mIns was performed using MICEST technique on ~20 months old APP-PS1 transgenic mouse model of AD as well as on age matched wild type (WT) control (n=5). Using the endogenous MICEST technique brain mIns concentration and glial cells proliferation can be mapped at high spatial resolution. ![]() mIns exhibits a concentration dependent chemical-exchange-saturation-transfer (CEST) effect (MICEST) between its hydroxyl groups and bulk water protons. Myo-Inositol (mIns) is a marker of glial cells proliferation and has been shown to increase in early Alzheimer’s disease (AD) pathology. ![]()
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